Una ricerca italo-americana ha messo in luce il coinvolgimento di un nuovo gene nell'insorgenza della Sclerosi laterale amiotrofica. Si tratta del gene VCP (Valosin Containing Protein), which is located on chromosome 9.
The study, published in the journal Neuron, and that will be discussed at the next World Congress on the SLA to be held in Orlando these days, was made possible through the collaboration of four research centers: the Center of the Department of ALS Neuroscience University of Turin and the Turin Molinette Hospital (coordinated by Professor Adriano Chio), the Laboratory of Neurogenetics NIH, Bethesda - USA (coordinated by Professor Bryan Traynor), the ALS Center at the University Hospital of Modena ( coordinated by Dr Jessica Mandrioli) and the molecular genetics laboratory of the OIRM Sant'Anna Hospital (directed by Dr. Gabriella Restagno).
The discovery was made possible through the use of revolutionary new technology of ESOMAR, thanks to which it is possible that part of the entire DNA sequence coding for the proteins . The technique has been used for the first time in studies of ALS. The new gene was already known as the cause of another neurological disease (frontotemporal dementia associated with inclusion body myositis and in Paget's disease), but above all, besides being the cause of Lou Gehrig's disease (now famous name in the field sports), is the first gene found to interfere with the process of accumulation of proteins anormali nelle cellule nervose. Infatti i motoneuroni nella Sla muoiono per accumulo di tali proteine aberranti. La scoperta di questo nuovo gene rappresenta pertanto una svolta fondamentale per la comprensione di questa terribile patologia ed offre prospettive per l’identificazione di terapie per il suo trattamento.
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Doriana
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